Late Adverse Events of Radiotherapy with Concomitant Cisplatin and the Response to Them

Dysphagia is a late adverse event of radiotherapy with concomitant Cisplatin (CDDP-RT), and patients advanced laryngeal cancer who undergo CDDP-RT have an impaired swallowing-related quality life. induced by has two major causative factors: delayed or untimely swallowing reflexes caused xerostomia oral oropharyngeal mucosal sensory disturbance decrease in perception, elevation disorder, inadequate relaxation the cricopharyngeal region, other problems function due to effects RT on larynx, pharyngeal contractile muscles, parts neck. Oral healthcare dysphagia rehabilitation are considered essential for requiring CDDP-RT, such support system needs be established at facility question. Future clinical trials (JCOG1912) will help clarify whether not reducing dose prophylactic irradiation area can mitigate events while maintaining treatment efficacy. Induction chemotherapy may able reduce extent tumor irradiation. However, this yet been proven, further studies larger cohorts needed.